The Success Of Mycobacterium Tuberculosis - think
Throughout human history, our species has come into contact with both harmless and infectious microbes that have changed us, like gut bacteria and retroviruses. But more recent infectious disease outbreaks have also left their mark on human biology. New research reported in the American Journal of Human Genetics has suggested that tuberculosis TB has had a variety of influences on human biology, including the genome. In this research, the investigators focused on changes in one gene called TYK2, which has been associated with the function of the immune system. Previous work has indicated that a homozygous variant in that gene called PA is linked to an increase in the risk of a serious illness due to Mycobacterium tuberculosis. By assessing a dataset containing genomic information from 1, ancient Europeans, the researchers determined that the PA variant emerged over 30, years ago. Further study that went beyond genomes suggested that the variant became far less frequent around 2, years ago. The Success Of Mycobacterium Tuberculosis.
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Bio-protocol20 Nov10 22 : e DOI: Read article at publisher's site DOI : PLoS Pathog, 2 :e Front Microbiol, Gengenbacher MKaufmann SH. Guirado ESchlesinger LS. Front Immunol, 98 Elife Stem Cell Res, PLoS One, 1 :e Tuberculosis Edinb Take part in our Impact Survey 15 minutes. Europe PMC requires Javascript to function effectively. Recent Activity. Recent history Saved searches.
Abstract Read article for free, via Unpaywall a legal, open copy of the full text. Search articles by 'Damien Portevin'. Portevin D 1. Affiliations 2 authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook.
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A better understanding of the complex host- Mtb interactions within the granuloma's environment may lead to new therapeutic or preventive tools to improve the control of the tuberculosis pandemic. To date, several in vitro models that are able to mimic human nascent granulomas have been reported. Here we describe a protocol in which Mtb -infected human peripheral blood mononuclear cells PBMCs are embedded within a collagen matrix leading to the formation of three-dimensional micro-granulomas.
Tubeerculosis, PBMCs and Mtb can be retrieved allowing multiparametric readouts from both the host and the pathogen. In addition to the incorporation of a physiological extracellular matrix, this model has the singular advantage of recapitulating dormant-like Mtb features, as well as reproducing Mtb resuscitation Succees under immunomodulatory treatments, which have not The Success Of Mycobacterium Tuberculosis reported in other published protocols The Success Of Mycobacterium Tuberculosis generate in vitro granulomas. Mycobacterium tuberculosis: success through dormancy. Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model. Functional characterization and phenotypic monitoring of human hematopoietic stem cell expansion and differentiation of monocytes and macrophages by whole-cell mass spectrometry.
Human granuloma in vitro model, for TB dormancy and resuscitation. Dissecting host factors that regulate the early stages of tuberculosis infection.
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