Does not: Gabapentin Versus Lorazepam Which Drug Is More
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Don't Take This With That: Grapefruit, Drug InteractionMetrics details. Carpal tunnel syndrome CTS is a common upper limb entrapment neuropathy; severe cases are treated surgically and mild to moderate can be managed conservatively.
Publication types
The purpose of this systematic review and meta-analysis was to define Gabapentin Versus Lorazepam Which Drug Is More efficacy of gabapentin as an adjuvant to splinting in the treatment of mild to moderate CTS. A systematic search through 13 databases, randomized clinical trials RCTs reporting the use of gabapentin with splinting in CTS were included and analyzed. Three RCTs including patients were eligible. This review provides low-quality evidence that gabapentin plus nocturnal splinting is not superior to splinting alone. More high-quality trials are needed to determine the role of this drug as an adjuvant in the management of CTS. Here tunnel syndrome CTS is a chronic compressive neuropathy resulting from compression of the median nerve at the wrist and considered to be the most common type of upper limb entrapment neuropathy seen in adults in outpatient clinics [ 1 ].
It affects 5. It has a prevalence rate of 7. Although surgical treatment ensures relief of symptoms, it should be only indicated in severe cases with persistent symptoms because of the high cost and possible complications such as infection, nerve injury, tendon injury, and complex regional pain syndrome [ 4 ]. Conservative measures are considered as the first-line treatment in mild or moderate cases more info as splints, non-steroidal anti-inflammatory drugs, physical therapy, and local steroid injections [ 5 ].
Wrist splinting and immobilization in a neutral position is the most popular conservative modality. Oral treatments such as Gabapentin, an antiepileptic drug structurally related to gama-amino butyric acid GABAis proposed to be effective for the treatment of neuropathic pain as diabetic neuropathy and post-herpetic neuralgia [ 67 ].
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According to Hui et al. Its benefit, however, as an adjuvant to splinting is still controversial [ 91011 ]. Therefore, the purpose of this systematic review and meta-analysis was to determine the effectiveness of gabapentin as an adjuvant to splinting versus splinting alone as a conservative line of CTS management. Two reviewers independently performed an electronic search on 13 databases to retrieve all potentially relevant articles to the research subject. There was no search filtering applied regarding Dug, year, and design. Results from scanned databases were grouped into one Endnote library to remove duplications.
Introduction
Two reviewers independently screened titles and abstracts of articles imported into Endnote for eligibility concerning inclusion and exclusion criteria. We included RCTs reporting the use of Gabapentin Versus Lorazepam Which Drug Is More as an adjuvant to splinting as a conservative line of CTS management. A manual search was carried out using references of the included studies, looking for similar articles in PubMed and Google Lkrazepam. Similar to the screening method, two reviewers were responsible for data extraction. A template in Microsoft Excel was used to report baseline characters and inspected outcomes. All data has been checked by the senior author. All data were Gabapentin Versus Lorazepam Which Drug Is More using R statistical software version 3. First, mean difference MD An Analysis of of in, standardized mean difference SMDand associated standard errors Se were calculated for the intervention gabapentin plus splinting versus control click alone groups.
A fixed-effect model with the method of Mantel-Haenszel [ 15 ] was used when there is no evidence of heterogeneity between studies. Otherwise, a random-effects model with the method of DerSiomonian and Laird was chosen [ Verus ]. Heterogeneity Versud studies was evaluated using the Q statistic and I 2 test which describes the percentage of variability in the effect estimates [ 1617 ]. The electronic search yielded references from the 13 databases.
Only three studies [ 91011 ] fulfilled the inclusion criteria, and the manual search of references did not import any additional articles. The eligible three articles included participants intervention and 70 control collectively, the mean age for intervention and control was All three studies included only patients with mild to moderate idiopathic CTS.
Degree of severity was defined based on clinical findings such as thenar atrophy and EMG findings.]
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