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The persecution of Christians in the Roman Empire occurred throughout most of the Roman Empire 's history, beginning in the 1st century AD. Originally a polytheist empire in the traditions of Roman paganism and Hellenistic religion , the Christianization of the Roman Empire brought early Christianity into ideological conflict with the imperial cult and the practice of making sacrifices to the deified emperors, which violates Christianity's prohibition on idolatry ; Christians were punished for not conforming to officially-sanctioned religious norms. General persecution of Christians in the empire began with the Neronian persecution under the emperor Nero r. The augustus Diocletian r. After Constantine the Great r. Romans, for the most part, were tolerant in matters of religious belief and allowed many religious sects and cults to proselytize without restrictions. Private belief was not a matter of interest to the Roman authorities. Social cohesion was based on obedience to authority and on public pledges of loyalty to the state; the latter was epitomized by symbolical sacrifices to the Roman gods. Rather, Roman authorities persecuted whoever refused to pledge loyalty to the state. Since Christians refused to sacrifice to the Roman gods the equivalent of an oath of allegiance , persecution followed; this included harassment at the local level, and officially sanctioned or decreed persecution.To What Extent Should We Embrace the Video
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Corey J. Langer, MD, discusses treatment options for a patient with non—small cell lung cancer based on the clinical trial research. There is a mind-set that carboplatin is a palliative drug—the metastatic stage IV recurrent drug—and cisplatin is the standard in the curable setting.
Every other trial used cisplatin. The trial overall was negative, but in the 4 [cm] or bigger group, which is what this patient has—a 5.
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The hazard ratio was 0. Which parameters are important when Ws on whether to use adjuvant systemic therapy post resection? Lymphovascular [invasion] puts patients at high risk. In my gut, I think those [patients] need it, but intellectually, at least prospectively, we have not [proven it]. Visceral pleura [invasion]—I know it upstages patients, but that in and of itself does not reduce prognosis. There is the potential for toxicities with renal insufficiency.
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Adjuvant cisplatin-based chemotherapy is recommended for patients with node-positive [disease] and now for patients in stage II with larger lesions—[stage] IB for those [with] high-risk features. Which trials show relevant data on the use of radiation therapy in this setting? They could have received neoadjuvant or adjuvant therapy.
They were stratified based on whether they [received] postoperative or preoperative chemotherapy; their node status, multistation versus single station; whether they had a PET; and histology. The primary end point was disease-free survival [DFS].
Secondary end points were article source survival [OS], the pattern of relapse, local failure, second cancers, and To What Extent Should We Embrace the. Numerically, it was better; it was How do past trials for adjuvant EGFR -targeted therapy compare for this patient population?
There was a DFS advantage in [the erlotinib] group [with mutations], but, over time, that difference, which was at least initially statistically significant, lost its significance and there was no OS advantage. There was an interesting observation. The treatment continued for 2 years, and after that 2-year point, there was an abrupt drop-off in the DFS, suggesting that these drugs may work but [only when patients are taking] them. There was an accelerated pattern of relapse once the drug was stopped. They did hhe give chemotherapy routinely to all these patients. Stratification was by stage, the nature of the mutation, and ethnicity—Asian versus non-Asian.]
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