Special case: Breast Cancer Reflection
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| Breast Cancer Reflection | Jun 01, · Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast cancer Cited by: Feb 10, · It's like your hair, your breast -- it's a reflection of who we are as women.” Ponde, a year-old Indian expat living in Singapore, gave birth to her son in April Sep 30, · Although breast self-examination does not reduce the incidence of breast cancer, it does markedly reduce the rate of mortality, since most early tumors are found by women themselves. I discovered my own tumor upon a monthly breast . |
Breast Cancer Reflection Video
Left-right difference in breast cancer inspires new research - Ann Ramsdell - TEDxColumbiaSCBreast Cancer Reflection - all
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Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. Our Breast Cancer Reflection highlight the differences between distinct breast cancer cell types and identify targets such as JAK2 and Stat3 that may lead to more specific and effective breast cancer therapies.
Lauren Canced. Kim, Sibgat A. Mulvey, Marina O. Anderson, Andrea L. Shirley Liu, David E. Root, William C. Hahn, David A. Frank, Kornelia Polyak. Triple-negative breast cancer read more is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies.
BL1 and BL2 subtypes had higher expression of cell cycle and DNA damage response genes, and representative cell lines preferentially responded to cisplatin.
The LAR subtype includes patients with decreased relapse-free survival and was characterized by androgen receptor AR signaling. LAR cell lines were uniquely sensitive to bicalutamide an AR antagonist. These data may be useful in biomarker selection, drug discovery, and clinical trial design that will enable alignment of TNBC patients to appropriate targeted therapies. Treatment of patients with triple-negative breast cancer BrreastBreast Cancer Reflection estrogen receptor ER and progesterone receptor Breast Cancer Reflection expression as well as human epidermal growth factor receptor 2 HER2 amplification, has been challenging due to the heterogeneity of the disease and the absence of well-defined molecular targets 1 — 3.
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TNBC tumors are generally larger in size, are of higher grade, have lymph node involvement at diagnosis, and are biologically more aggressive 5. Despite having higher rates of clinical response to presurgical neoadjuvant chemotherapy, TNBC Breast Cancer Reflection have a higher rate of distant recurrence and a poorer prognosis than women with other breast cancer subtypes 56. Clearly, there is a major need to better understand the molecular basis of TNBC and to develop effective treatments for Breast Cancer Reflection aggressive type of breast cancer.
More extensive genomic, molecular, and biological analyses of TNBCs are required to understand the complexity of the disease and to identify molecular drivers that can be click targeted. We identified 6 TNBC subtypes.
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Using the panel of cell lines, we pharmacologically targeted prominent signaling pathways revealed by GE signatures and found that the cell lines representing the various subtypes had different sensitivities to targeted therapies currently under laboratory and clinical investigation. The identification of diverse TNBC subtypes and the molecular drivers in corresponding cell line models provides Breast Cancer Reflection insight to the heterogeneity of this disease and provides preclinical platforms for the development of effective treatment.
GE profiles were obtained from 21 publicly available data sets that contained 3, primary human breast cancers and processed according to the flow chart in Figure 1 A.]
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